Dynamic visualization of RANKL and Th17-mediated osteoclast function
نویسندگان
چکیده
منابع مشابه
Dynamic visualization of RANKL and Th17-mediated osteoclast function.
Osteoclasts are bone resorbing, multinucleate cells that differentiate from mononuclear macrophage/monocyte-lineage hematopoietic precursor cells. Although previous studies have revealed important molecular signals, how the bone resorptive functions of such cells are controlled in vivo remains less well characterized. Here, we visualized fluorescently labeled mature osteoclasts in intact mouse ...
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The process of osteoclastic bone resorption is complex and regulated at multiple levels. The role of osteoclast (OCL) fusion and motility in bone resorption are unclear, with the movement of OCL on bone largely unexplored. RANKL (also known as TNFSF11) is a potent stimulator of murine osteoclastogenesis, and activin A (ActA) enhances that stimulation in whole bone marrow. ActA treatment does no...
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© 2008 Pappu et al. The Rockefeller University Press $30.00 J. Exp. Med. Vol. 205 No. 5 1049-1062 www.jem.org/cgi/doi/ 1049 10.1084/jem.20071364 After activation, CD4 + Th cells diff erentiate into distinct eff ector subsets that are characterized by their unique cytokine expression and immunoregulatory function ( 1, 2 ). A novel Th subset — termed Th IL-17 , Th17, or infl ammatory Th — has bee...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2013
ISSN: 0021-9738
DOI: 10.1172/jci65054